At a church where the migrants had been staying on Martha's Vineyard, migrants cheered Friday morning when they heard the Massachusetts government would shelter them at a Cape Cod military base.
They embraced each other and locals before boarding buses provided by state and local government for their journey to the base.
A volunteer helping the migrants was among those hugging them, and was in tears as they departed.
"This was another person's -- multiple peoples' -- really difficult moment in their life, and they shared it with us with such grace and affection and humor. And to be welcomed into their lives and into their hearts was a gift," Lisa Belcastro said.
A group of civil rights attorneys working with the migrants said their stories are "heartbreaking -- and infuriating." Many of the migrants went to a hospital in need of care upon their arrival to the island on Wednesday.
Some of these migrants were sent to Martha's Vineyard even though they have immigration hearings scheduled that are nowhere near Massachusetts, the group said. Migrants released from government custody often move to other cities in the US as they go through their immigration proceedings.
"This cowardly political stunt has placed our clients in peril," the Lawyers for Civil Rights group said in a news release Friday. "Some now have immigration hearings as early as Monday thousands of miles away."
Some attorneys from the group accompanied the migrants on the buses headed to the Cape Cod base.
The help that awaits the migrants on Cape Cod
Joint Base Cape Cod -- already an emergency shelter designated by the state emergency management agency -- is set up to provide "a safe temporary accommodation appropriate for the needs of families and individuals," the governor's office said in a release.
The migrants "will be housed in dormitory-style spaces at JBCC, with separate spaces accommodating both individuals and families," and families will not be separated, the release reads.
They will have access to services including legal, health care, food, hygiene kits, and crisis counseling, according to Baker's office.
Baker, a Republican, lauded a temporary shelter that the Martha's Vineyard community set up for the migrants in "a moment of urgent need."
"We are grateful to the providers, volunteers and local officials that stepped up on Martha's Vineyard over the past few days to provide immediate services to these individuals," Baker said in a news release.
White House denounces DeSantis' move
Despite Wednesday's unannounced arrivals on Martha's Vineyard, some residents of the island worked quickly to provide some key services.
Hagerty said overall the "outpour was tremendous" and reiterated the island community answered the call to help when migrants arrived without notice earlier this week.
"Sometimes we're alone and unafraid out here, but we understand the path of travel and we understand we're a community that ultimately wants to help people," Hagerty said.
CNN's Maria Santana, Amy Simonson, Priscilla Alvarez and Devan Cole contributed to this report.